NIH Awards Cedars-Sinai Over $12 Million to Study How Viral Infections Trigger Pulmonary Fibrosis
Cedars-Sinai in Los Angeles announced on November 13 that it has received more than $12 million over five years from the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health (NIH), to study how viral infections trigger irreversible pulmonary fibrosis, the scarring of lung tissue.
The award brings together 12 investigators across three research projects and four shared cores. A Cedars-Sinai team led by Ping Chen, MD, PhD, studies how viruses reprogram lung stem cells; Jie Sun's team at the University of Virginia examines the immune microenvironment in fibrosis; and Cedars-Sinai's Xue Liu studies the cell-signaling pathways involved. The groups will share data and samples to map the full chain from infection to scarring.
Pulmonary fibrosis is a progressive lung disease in which tissue stiffens and loses elasticity; there is no cure, and some patients develop or worsen after respiratory viral infections. The researchers say understanding how viruses set fibrosis in motion is a prerequisite for finding drug targets that can block it.
(Source: Cedars-Sinai)
Source: Cedars-Sinai
Published by GSM · USA (original Chinese edition)
Photo: Wikimedia Commons：File:Cedars-Sinai Los Angeles Mark Goodson Building Los Angeles County California 2024 Feb.jpg（开放授权）
