Halomonas Strain D23 Shows Quorum-Quenching Activity, Degrading Fish Pathogen Signaling Molecules Within 12 Hours
A study published November 14 in Scientific Reports evaluated Halomonas strain D23 as a candidate probiotic for aquaculture. The authors are Ghosh, Alam, and Mukhopadhyay. The strain has quorum-quenching activity, degrading the signaling molecules that fish pathogens use to communicate.
In experiments, D23 tolerated 1.2 percent bile salt and 0.75 percent phenol and survived acidic conditions of pH 2.0 to 4.0. Its antioxidant activity exceeded 69 percent, auto-aggregation was 72.0 percent (plus or minus 2.42 percent), and co-aggregation with fish pathogens exceeded 73 percent. D23 degraded the natural N-AHLs of Aeromonas hydrophila within 12 hours, and its anti-biofilm effect in co-culture reached a p value of 0.0001 or lower.
Genome analysis detected no virulence genes and no plasmid- or transposon-associated genes, and only very few resistance genes. The study also identified a putative lactonase, lactonase_D23, carrying a 66HXHXDH71 motif.
Source: Scientific
Published by GSM · USA (original Chinese edition)
Photo: 图：希腊 Euboea 岛 Amarynthos 近海的鱼类养殖网箱。来源：Jebulon，Wikimedia Commons，CC0 1.0。 / Photo: Fish farming cages off Amarynthos on the Greek island of Euboea. Source: Jebulon, Wikimedia Commons, CC0 1.0.
