Microbiome Analysis of 940 Lung Cancers in Never-Smokers Finds No Clinically Relevant Associations
A study published in Nature Communications analysed the microbiome of 940 lung cancers in never-smokers and found a lack of clinically relevant associations. The manuscript was received on 29 May 2025, accepted on 14 November 2025 and published on 12 December 2025.
The team applied stringent quality-control criteria to tumour samples, excluding samples with certain mutational signatures and requiring thresholds for total genomic alteration counts and reads per clonal copy to ensure data robustness.
The work was conducted within the Sherlock-Lung study. The authors said the negative finding helps clarify inconsistent earlier reports on lung cancer microbiome associations.
Source: Nature Communications
Published by GSM · USA (original Chinese edition)
Photo: 肺腺癌的组织病理图像。照片：Chen CL等，CC BY 4.0，经 Wikimedia Commons / Lung adenocarcinoma histopathology. Photo: Chen CL et al., CC BY 4.0, via Wikimedia Commons
