Spinal Cord Study: Thiorphan Raises Neurite Outgrowth 1.8-Fold, Improves Forelimb Function with Stem Cell Graft
A study published in Nature on October 29, 2025 used in silico screens to identify thiorphan, a neutral endopeptidase inhibitor, as a lead candidate that reprograms neurons to promote functional recovery after spinal cord injury.
Thiorphan increased neurite outgrowth 1.8-fold. When infused into the central nervous system and combined with a neural stem cell graft, it elicited significant improvements in forelimb function.
The screen was based on an embryonic shift in the corticospinal motor neuronal transcriptome after spinal cord injury that is associated with successful axonal regeneration, the researchers said.
(Source: Nature)
Source: Nature
Published by GSM · USA (original Chinese edition)
Photo: 图：脊髓横截面示意图。OpenStax 作，CC BY 4.0，经 Wikimedia Commons。 / Photo: Cross section of the spinal cord (diagram). By OpenStax, CC BY 4.0, via Wikimedia Commons.
