Nature Communications Paper of November 6: Two Types of Salmonella Serovars Use Opposing Pre-Invasion Strategies to Sense and Invade Human Intestinal Epithelium, From McKenna, Geier and Monack
A paper published in Nature Communications on November 6 by McKenna, Geier, Monack and colleagues compares the strategies that two types of Salmonella enterica serovars use before invading human intestinal epithelium. The authors note that generalist serovars cause gastroenteritis while human-restricted serovars cause typhoid fever, and that the two types use opposing pre-invasion strategies to sense and invade the human intestinal epithelium.
According to the paper's abstract, the two serovar types move in opposite directions in how they approach the epithelium, recognize their target and initiate invasion, a mirror-image difference at the earliest stage of infection. The authors present this as evidence that serovar divergence within the species shows up not only in disease presentation — gastroenteritis versus typhoid fever — but also in the first contact with host tissue.
The paper is a formally published, peer-reviewed article. Its first author is Joy A. McKenna, with Benedikt Geier as co-author and Denise M. Monack as corresponding author. Experimental data, samples and mechanistic detail are as given in the journal text; this report relays only the published abstract's comparison of the two strategies and draws no clinical conclusion.
Source: Nature Communications
Published by GSM · USA (original Chinese edition)
Photo: 图：沙门氏菌显微图。Wikimedia Commons 供图，公共领域，经 Wikimedia Commons。 / Photo: Salmonella bacteria under a microscope. By Wikimedia Commons 供图, public domain, via Wikimedia Commons.
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