Dynamic Accommodative Stress Testing Separates Subclinical Keratoconus in a 180-Person Study: A Dynamic Ectasia Index Sensitivity of 98.3 Percent and Specificity of 96.7 Percent, in Scientific Reports on November 12
A prospective diagnostic accuracy study published in Scientific Reports on November 12, 2026, used dynamic accommodative stress testing for early detection of subclinical keratoconus. Combining Scheimpflug-Placido imaging with anterior segment optical coherence tomography, the study examined anterior segment changes during accommodative effort in 180 participants, one eye each, allocated to three age-matched groups of 60, namely bilateral subclinical keratoconus, very asymmetric ectasia with clinically unaffected fellow eyes, and healthy controls. The authors are Burhan Başkan and Yusuf Evcimen, and the paper carries digital object identifier 10.1038/s41598-026-79398-x. Two composite indices, the Dynamic Ectasia Index and the Corneal Thickness Redistribution Index, were derived from the dataset after data collection and were not prespecified. The journal abstract reported that at 6 diopters, subclinical keratoconus eyes deformed more than controls in every primary outcome, including an anterior chamber depth change of minus 0.114 plus or minus 0.021 millimeters versus minus 0.069 plus or minus 0.015 millimeters, and an inferotemporal curvature change of 1.76 plus or minus 0.27 diopters versus 0.66 plus or minus 0.17 diopters, both with p below 0.001. The abstract reported that the Dynamic Ectasia Index separated subclinical keratoconus from control eyes with 98.3 percent sensitivity and 96.7 percent specificity, with an area under the curve of 0.995 and a 95 percent confidence interval of 0.989 to 1.000. The authors stated plainly that all estimates were derived and evaluated in the same dataset and are therefore optimistic, that the indices should be interpreted as screening composites rather than biomechanical parameters, and that external validation in independent cohorts is required before clinical use.
(Source: Scientific)
Source: Scientific
Published by GSM · USA (original Chinese edition)
Photo: 图：一名眼科医生正在为受检者做眼部检查。Tony Webster，CC BY 2.0，经 Wikimedia Commons。 / Photo: Tony Webster, CC BY 2.0, via Wikimedia Commons.
[Video] ULA Vulcan Return to Flight Slips One Day: Nitrogen Plant Outage Pushes Launch of 40 Amazon Leo Satellites to Saturday Midday2026-11-14
Murine Splenic CD45-Positive Erythroid Cells Carry Antigen-Presenting Cell Transcriptomic Signature, With MHC Class II Module Comparable to Monocytes, Published in Scientific Reports on November 132026-11-14