A Growth Hormone Study Enrolls 148 Women Aged 35 and Older: 4.5 International Units Daily for Five Days, Published in Scientific Reports on November 12
A study published in Scientific Reports on November 12, 2026, examined the effect of recombinant human growth hormone during ovulation induction with a GnRH agonist long protocol on IVF-ET outcomes in women aged 35 and older with different ovarian responsiveness. A total of 148 female patients aged 35 and above undergoing controlled ovarian hyperstimulation with the long protocol were selected. The paper carries digital object identifier 10.1038/s41598-026-64818-9. The growth hormone group received a daily injection of 4.5 IU of recombinant growth hormone, initiated from the starting day of gonadotropin and lasting five days. Participants were divided by oocytes retrieved, with at least four classed as normal ovarian response and fewer than four as ovarian hyporesponsiveness, and outcomes were compared within the age bands 35 to 37, 38 to 40, and 41 and above. The journal abstract reported that in the normal response group there was no statistically significant difference at ages 35 to 37, that the number of 2PN fertilizations and cleavage embryos was significantly higher with growth hormone at ages 38 to 40, and that oocytes retrieved, mature oocytes and cleavage embryos were significantly higher with growth hormone at ages 41 and above. In the hyporesponsive group, 2PN fertilizations, cleavage embryos and the high-quality embryo rate were significantly higher with growth hormone at ages 38 to 40. Clinical pregnancy rates and implantation rates were somewhat improved in the growth hormone group across response groups, but without statistical difference. The authors noted the relatively small sample size in the normal-response group aged 38 and above and said larger cohort data are needed for more solid conclusions.
(Source: Scientific)
Source: Scientific
Published by GSM · USA (original Chinese edition)
Photo: 图：一名研究人员正用移液器从微型试管中取样。Maggie Bartlett，公共领域，经 Wikimedia Commons。 / Photo: Maggie Bartlett, public domain, via Wikimedia Commons.
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