Dengue Virus Strains Show High Genomic Diversity: 411 Index Cases across 30 Sites in 7 Countries, Scientific Reports Finds All Four Serotypes Cocirculating in Latin America and Asia-Pacific
Belgium — Scientific Reports published a dengue virus genomic study on November 11, 2026, by Van Eygen, Vijgen, Hong and colleagues. The data come from the Phase 2 clinical trial of mosnodenvir prophylaxis, registered as NCT05201794, conducted in endemic regions of Asia-Pacific and Latin America in 2023 to 2024.
The study involved 411 dengue index cases, with serotypes determined using RT-PCR. Whole-genome sequencing was conducted for a subset of 150 index cases representing the dengue serotypes observed over time at 30 sites across 7 countries.
Cocirculation of all four dengue serotypes was observed in both Latin America and the Asia-Pacific region. Overall, dengue serotype 1 was predominant at 51.1 percent, with significant geographical variation in genotype distribution: serotype 1 genotype V in Latin America versus genotypes I and IV in the Asia-Pacific region.
The study also identified increased circulation of serotype 3 and serotype 4 strains in Latin America during 2023 to 2024. Time-resolved phylogenetic analyses show the study captured a broad cross-section of contemporary dengue diversity circulating across Latin America and the Asia-Pacific region during that period. All figures in this report follow the abstract of the paper.
Published by GSM · USA (original Chinese edition)
Photo: 图：图中是一只埃及伊蚊正在叮咬人手。图中是埃及伊蚊的实物照片，埃及伊蚊是登革病毒的主要传播媒介之一。Original author: US Department of Agriculture; then denoised，Public domain，经Wikimedia Commons。 / Photo: file photo. Original author: US Department of Agriculture; then denoised, Public domain, via Wikimedia Commons.
Study of Nearly 100,000 Americans Finds Thousands of New Drug-Gene Variants: At Least One Variant in 16 Pharmacogenes in Every Participant, One in Four Had Taken an Affected Medicine2026-11-11
Blood Multi-Biomarker Panel Discriminates Alzheimer Disease from Healthy Controls: 200 Participants and 12 Markers, Scientific Reports Model Reaches AUROC of 0.9999 with External Validation Still Required2026-11-11